TAK-243 preferentially sure to UBA1 more than the linked E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced amounts of ubiquitylated proteins, elevated markers of proteotoxic pressure and DNA injury worry. In vivo, TAK-243 minimized leukemic stress and focused leukemic stem cells with https://judahqkcrf.link4blogs.com/51134514/cb-6644-for-dummies