At this time, there are two kinds of experiments on itaconate: Irg1−/− macrophages and the regulatory effect of itaconate derivatives. Both of these outcomes ended up complementary and disclosed that the regulatory mechanisms of itaconate concerned alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription aspect 3 (ATF3) https://josephm776yku9.nytechwiki.com/user