If a guardian of your proband is known to provide the pathogenic variant discovered inside the proband, the danger into the sibs of inheriting the pathogenic variant is 50%. As a consequence of decreased penetrance, sibs who inherit the pathogenic variant might or might not establish aHUS (see Penetrance). AHUs https://ahuhire49360.boyblogguide.com/31614100/air-handling-units-ahus-no-further-a-mystery