If a mother or father on the proband is understood to contain the pathogenic variant identified during the proband, the risk into the sibs of inheriting the pathogenic variant is 50%. Thanks to decreased penetrance, sibs who inherit the pathogenic variant might or might not develop aHUS (see Penetrance). RTU’s https://ahu-s37047.develop-blog.com/40015148/how-ahu-s-can-save-you-time-stress-and-money