The Drosophila Mad1 spindle checkpoint protein helps organize several nucleoplasmic components. and flies lacking Mad1 present changes in gene expression reflecting altered chromatin conformation. In interphase. checkpoint protein Mad1 is usually described as localizing to the inner nuclear envelope by binding the nucleoporin Tpr. https://www.markbroyard.com/deal-time-gtech-airram-mk2-k9-roller-roll-brush-bar-filter-vacuum-cleaner-hot-on-sale-best-find/