There is a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to decrease afferent discomfort transmission and develop analgesia. Thus, medicines like clonidine that focus on alpha-two receptors can impact the transmission of discomfort. May be supplied as monotherapy or https://www.proleviate.com/post/the-new-pain-killer-conolidine