Study into conolidine has resulted in discovery of an opioid receptor in the human body termed ACKR3/CXCR7. ACKR3 is apparently by far the most popular goal for conolidine, which also disregards another four classical opioid receptors(three). Conolidine has been found in the tabernaemontana divaricata plant, that's inside the Apocynaceae https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers